pI: 6.4294 |
Length (AA): 1673 |
MW (Da): 186114 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_130417)
Species | Accession | Gene Product |
---|---|---|
Caenorhabditis elegans | CELE_T27B1.1 | Protein OSM-1 |
Drosophila melanogaster | Dmel_CG13809 | Outer segment 2 |
Echinococcus granulosus | EgrG_000617200 | intraflagellar transport protein 172 |
Echinococcus multilocularis | EmuJ_000617200 | intraflagellar transport protein 172 |
Giardia lamblia | GL50803_17105 | IFT complex B |
Homo sapiens | ENSG00000138002 | intraflagellar transport 172 |
Leishmania braziliensis | LbrM.21.1210 | hypothetical protein, conserved |
Leishmania donovani | LdBPK_211220.1 | intraflagellar transport protein 172, putative |
Leishmania infantum | LinJ.21.1220 | hypothetical protein, conserved |
Leishmania major | LmjF.21.0980 | hypothetical protein, conserved |
Leishmania mexicana | LmxM.21.0980 | hypothetical protein, conserved |
Loa Loa (eye worm) | LOAG_04604 | hypothetical protein |
Loa Loa (eye worm) | LOAG_14257 | hypothetical protein |
Loa Loa (eye worm) | LOAG_13357 | hypothetical protein |
Mus musculus | ENSMUSG00000038564 | intraflagellar transport 172 |
Neospora caninum | NCLIV_040690 | selective LIM-binding factor, putative |
Schistosoma japonicum | Sjp_0034460 | Intraflagellar transport protein 172 homolog, putative |
Schistosoma mansoni | Smp_130830 | wimple/ift172 |
Schmidtea mediterranea | mk4.000070.26 | IFT172-like protein |
Trypanosoma brucei gambiense | Tbg972.10.1210 | hypothetical protein, conserved |
Trypanosoma brucei | Tb11.0560 | hypothetical protein, conserved |
Trypanosoma brucei | Tb927.10.1170 | intraflagellar transport protein 172 |
Trypanosoma brucei | Tb11.v5.0858 | hypothetical protein, conserved |
Trypanosoma congolense | TcIL3000_10_970 | intraflagellar transport protein 172, putative |
Trypanosoma cruzi | TcCLB.509695.90 | intraflagellar transport protein 172, putative |
Toxoplasma gondii | TGME49_288050 | intraflagellar transport protein 172, putative |
Trichomonas vaginalis | TVAG_327960 | wimple/ift172, putative |
Trichomonas vaginalis | TVAG_061760 | osm-1, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
Tb927.10.1170 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (3 days) | alsford |
Tb927.10.1170 | Trypanosoma brucei | significant loss of fitness in bloodstream forms (6 days) | alsford |
Tb927.10.1170 | Trypanosoma brucei | significant loss of fitness in procyclic forms | alsford |
Tb927.10.1170 | Trypanosoma brucei | significant loss of fitness in differentiation of procyclic to bloodstream forms | alsford |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.